Activation of Protease-Activated Receptor-1 Causes Chronic Pain in Lupus-Prone Mice Via Suppressing Spinal Glial Glutamate Transporter Function and Enhancing Glutamatergic Synaptic Activity

•Spinal PAR1 plays an important role in the genesis of chronic pain in MRL/lpr mice.•Activation of PAR1 and suppression of AMPK activity in MRL/lpr mice with chronic pain.•Blockade of PAR1 or AMPK activation attenuated chronic pain in MRL/lpr mice.•Targeting the PAR1 and AMPK pathways may be a potent approach for treating chronic pain caused by SLE.