Platelet closure time in the evaluation of efficacy of CAR-T cell therapy in relapsed/refractory multiple myeloma
Research Square (Research Square)(2023)
摘要
Abstract Purpose In recent years, many studies of platelet function in multiple myeloma (MM) patients have been reported. However, the role of platelet function in relapse/refractory (R/R) MM after chimeric antigen receptor T (CAR-T) cell therapy remains to be clarified. Methods In this study, we investigated platelet closure time (PCT) in the evaluation of efficacy of CAR-T cell therapy in patients with R/R MM, clinical data of 50 patients were retrospectively analyzed. Collagen/adenosine diphosphate (CADP) and Collagen/Epinephrine (CEPI)-induced PCT of peripheral blood were detected by platelet function analyzer-200, respectively, with 20 healthy individuals as control. Results After the approach of CAR-T cell therapy, CADP PCT and CEPI PCT decreased significantly when compared with those before treatment: (67.22, 95% CI 46.91–87.53, P < 0.01) and (77.46, 95% CI 59.43–95.50, P < 0.01). CADP PCT was positively correlated with TT (r = 0.305, P = 0.047), ISS stage (r = 0.389, P = 0.005) and cytokine release syndrome (CRS) stage (r = 0.328, P = 0.020), whereas negatively associated with λ-type light chain (r = − 0.399, P = 0.014) and IgM (r = − 0.355, P = 0.017). In addition, patients who achieved >PR had a shorter PCT compared with those ≤ PR. Moreover, the PCT of patients with grade 3–5 CRS was considerably longer than grade 0–2 CRS after treatment. Conclusion PCT could be defined as a potential indicator in the evaluation of efficacy of CAR-T cell therapy.
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关键词
relapsed/refractory multiple myeloma,multiple myeloma,cell therapy,closure time
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