Incidence of febrile seizures in children with COVID-19

Abstract Purpose This study aimed to investigate the incidence of febrile seizures (FS) associated with coronavirus disease 2019 (COVID-19) in children and examine the variation in these incidences after the Omicron surge. Methods The number of confirmed COVID-19 cases aged below 5 years residing in the Jeonbuk province from January 2020 to June 2022 was obtained from official data released by the Korean government. During the same period, data regarding FS patients with COVID-19 were obtained from all local hospitals capable of FS treatment in Jeonbuk. The data were analyzed retrospectively. Results The number of children under 5 years of age in Jeonbuk was 62,772, of which 33,457 (53.2%) were diagnosed with COVID-19 during the study period. Of these, 476 patients (1.4%) required hospitalization and 64 (0.19%, 44 boys: 20 girls) developed FS. Until 2021, before the Omicron surge, 23.4% of the patients (89 of 381) required hospitalization, but no children with COVID-19 were hospitalized for FS. However, after the Omicron surge in 2022, 16.5% of hospitalized children (64 of 387) experienced FS, despite the decline in hospitalization rates among COVID-19 patients (1.2%). Twenty-five patients (39.1%) had complex FS, and one (1.6%) presented with febrile status epilepticus. Forty-two patients (65.6%) experienced first-time FS, with an average of 1.5 convulsive events. Conclusions During the COVID-19 pandemic, the incidence of FS was approximately 0.19%; however, after the emergence of the Omicron variant, FS occurred more frequently and became more complex.