Prediction score for clinical outcome of Chinese patients with cerebral venous thrombosis

Abstract Background: Despite a series of reported prognostic markers, there is no prediction score for clinical outcome of Chinese patients with cerebral venous thrombosis (CVT). This study is aimed to develop a CVT outcome score for Chinese. Methods: The study sample came from CCC cohort, which is a multicenter study participated by 26 top tertiary hospitals in China Mainland. 170 CVT patients were prospectively recruited from January 2021 to May 2022. The potential prognostic markers were extracted from CCC database and analyzed. Results: Age, diastolic blood pressure (DBP), neutrophil-to-lymphocyte ratio (NLR) and neuron specific enolase (NSE) were identified as prognostic markers for CVT after multivariate logistic analysis. Age > 27.5 years, DBP > 79.5mmHg, NLR > 6.6 and NSE >16.5 ng/ml were identified as cutoff values. One point was assigned to age and NSE, two points were assigned to DBP and three points were assigned to NLR based on adjusted odds ratio. CVT outcome score at baseline was positively correlated with mRS at 6 months of follow-up. CVT outcome score effectively predicted the clinical outcome of CVT with a cutoff value of 3.5. Further analysis showed that patients with CVT outcome score > 3 had significantly higher mRS than those with CVT outcome score ≤3. Conclusions: CVT outcome score consists of age, DBP, NLR, and NSE for Chinese CVT patients was developed in this study. CVT outcome score at baseline positively correlated with mRS at 6 months of follow-up. CVT outcome score > 3 helps to identify CVT patients with high risk of poor clinical outcome and take early interventions to prevent deteriorations.