Maresin1 ameliorates ventricular remodelling and arrhythmia in mice models of myocardial infarction via NRF2/HO-1 and TLR4/NF-kB signalling

Fengyuan Wang,Yang Gong,Tao Chen,Bin Li,Wei Zhang,Lin Yin,Hongyi Zhao,Yanhong Tang,Xi Wang,Congxin Huang

International Immunopharmacology（2022）

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摘要

•Maresin1 attenuated post-MI oxidative stress injury by NRF2/HO-1 signaling.•Maresin1 inhibited TLR4/NF-kB signaling and the release of inflammatory cytokines after MI.•Maresin1 reduced myocardium apoptosis and fibrosis after MI.•Maresin1 decreased the susceptibility of ventricular arrythmias and improved cardiac function after MI.

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关键词

Maresin1,Myocardial infarction,NRF2/HO-1 signaling,TLR4/NF-kB signaling,Cardiac remodeling,Ventricular arrhythmias

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