Different Uses of 5-FLUROURACIL in Dermatology: Review Article

Background:The 5-FLUROURACIL (5-FU) is easily absorbed by all tissues after intravenous injection, even those with active cell proliferation such the spleen, small intestine, and bone marrow.Topical administration of 5-FU is the recommended method for treating dermatological diseases because of the significant cytotoxicity of 5-FU for growing cells.5-fluorouracil is offered as creams or solutions with concentrations ranging from 0.5 percent to 5 percent.Treatment requires two daily applications, although a controlled-release 0.5 percent microsphere formulation should only be used once daily.Objective: Assessment of uses of 5-FLUROURACIL in Dermatology practice.Methods: The 5-FLUROURACIL, transfer ribonucleic acid and dermatology were all looked for in PubMed, Google scholar, and Science direct.References from relevant literature were also evaluated by the authors, but only the most recent or complete study from March 2003 to November 2021 was included.Due to the lack of sources for translation, documents in languages other than English have been ruled out.Papers that did not fall under the purview of major scientific investigations, such as unpublished manuscripts, oral presentations, conference abstracts, and dissertations were omitted.Conclusion: The data we reviewed suggested that 5-FU might be useful for a variety of noncancerous cutaneous causes, including the treatment of scars, pigmentary diseases, cutaneous infections (viral warts, molluscum contagiosum), inflammatory dermatoses, and cosmetics purposes.