BNIP‐2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation (Adv. Sci. 31/2022)

BNIP-2 Activation of Cellular Contractility In article number 2202834 by Darren Chen Pei Wong, Pakorn Kanchanawong, Boon Chuan Low, and co-workers, the multifaceted roles of the scaffold protein, BNIP-2, are demonstrated to induce the expression of two cardiac markers, cTnT and Myl2, in H9c2 and hESC cells. During this process, BNIP-2 activation of contractility and scaffolding of LATS1 to Yes-associated protein (YAP) is required to inactivate YAP for cardiomyoblast differentiation.