Recent Advances in the Chemical Synthesis of beta-Nicotinamide Mononucleotide

b-Nicotinamide mononucleotide (beta-NMN), a key precursor in the biosynthesis of nicotinamide adenine dinucleotide (NAD(+)) in mammals, has significant effects in replenishing NAD(+) levels in the body, so it has obvious ameliorative effects on metabolic and age-related degenerative diseases. beta-NMN is widely used in healthcare products, food, and cosmetics. It has considerable commercial worth and promising medical application prospects. Hence, the development of methods for preparing beta-NMN is of great research significance. This review summarized and analyzed recent developments in the chemical synthesis of beta-NMN from various starting materials, which could provide helpful references for the investigation of new synthetic techniques for beta-NMN and encourage its further development and large-scale application.