Crosstalk between Aryl Hydrocarbon Receptor (AHR) Pathway and IL-13 Signaling in Human Keratinocytes and Implications for Atopic Dermatitis

Steven Proper, Andrews Appiagyei, Alexander Dwyer,Jennifer Felton,Netali Ben-Baruch Morgenste,Justin Marlman,Michael Kotliar,Artem BARSKI,Ty Troutman,Marc Rothenberg,Tesfaye Mersha,Nurit Azouz

Journal of Allergy and Clinical Immunology（2023）

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摘要

Atopic dermatitis (AD) is an allergic skin disease mediated by skin barrier dysfunction and an IL-13-driven immune response. The aryl hydrocarbon receptor (AHR) is a sensor molecule that is activated by numerus environmental ligands, some of which have shown promise in clinical trials of AD. Therefore, we hypothesized that the AHR pathway can attenuate IL-13-induced responses.

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关键词

atopic dermatitis,human keratinocytes,aryl hydrocarbon receptor

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