Transcriptomic analysis of airway epithelial cells identifies an altered expression profile of T2 and non-T2 genes in chronic rhinosinusitis with nasal polyposis

George Huang,Nils Hallen,Jonathan Hacker,Alanna McGill,Tessa Ryan,Regan Bergmark,Neil Bhattacharyya,Stella Lee,Alice Maxfield,Rachel Roditi,Kathleen Buchheit,Tanya Laidlaw,Joshua Boyce,Maria Gutierrez-Arcelus,Nora Barrett

Journal of Allergy and Clinical Immunology（2023）

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摘要

Aberrant differentiation of basal epithelial cells is a hallmark feature of chronic rhinosinusitis with nasal polyposis (CRSwNP). We hypothesized that unbiased transcriptomic analysis of upper airway epithelial cells at various stages of differentiation would identify genes fundamental to CRSwNP.

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关键词

chronic rhinosinusitis,transcriptomic analysis,epithelial cells,genes,airway

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