Unexpected Discovery of Saturated Pyridine Mimetics

Dmitry Dibchak, Mariya Snisarenko, Artem Mishuk,Oleg Shablykin, Lina Bortnichuk, Oleksii Klymenko-Ulianov, Yurii Kheylik, Iryna Sadkova,Henry Rzepa,Pavel Mykhailiuk

crossref（2023）

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摘要

A general approach to 3-azabicyclo[3.1.1]heptanes was unexpectedly discovered. The mechanism, scope, and scalability of this method were studied. The core was incorporated into the structure of the antihistamine drug Rupatidine instead of the pyridine ring, which led to a dramatic improvement in physicochemical properties.

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