Modeling Single Ventricle Morphology With a HLHS-Specific Biventricular Template to Enhance Statistical Shape and Biomechanics Analyses

Abstract Modeling the hearts of patients with hypoplastic left heart syndrome has remained an ongoing challenge. Thus, in this work, we developed a HLHS-specific biventricular template to capture the single ventricle morphology in this cohort accurately and robustly. We have demonstrated that using the HLHS-specific template to reconstruct patient-specific models from cardiac magnetic resonance images result in significantly higher accuracy comparing to that of using the generic template. Additionally, element distortion in meshes created using the HLHS-specific template is compatible with meshes currently used for finite element analysis. Accurate 3D patient-specific models will serve as powerful tools for subsequent statistical shape and biomechanics analyses to provide insights into remodeling of ventricular shape and function and their potential association with clinical outcomes.