Typhoid fever complicated by rhabdomyolysis with acute hepatitis, splenic infarct, pancreatitis, and acute kidney injury

Typhoid fever is a potentially life-threatening infectious disease that presents itself with a wide array of symptoms ranging from uncomplicated fever to sepsis with multiorgan dysfunction syndrome. An 18-year-old male college student presented with progressively increasing fever with abdominal discomfort, anorexia, and persistent vomiting. Typhoid fever was suspected in view of clinical findings along with leukopenia, grossly elevated transaminases, and acute kidney injury. He was managed with intravenous (IV) antibiotics, which resulted in the resolution of fever and other symptoms. Rhabdomyolysis is an extremely rare complication in typhoid fever, which is a very common cause of fever in tropical countries, leading to acute renal failure, causing very high morbidity and mortality.