Values of real-time three-dimensional left atrial-ventricular volumes in healthy adults

Abstract Objectives. The purpose of this study was to explore the effects of age and gender on left atrial-ventricular volumetric indices in healthy adults by left atrial-ventricular volume loops (LA-LV V-LOOPs) and provide novel insight into diagnosis and treatment of LA-LV abnormality. Methods. 57 healthy adults were involved. Transthoracic echocardiography was utilized to obtain conventional left heart function parameters and three-dimensional echocardiography(3DE) images. Then, dynamic heart model (DHM) was used to analyze 3DE images to obtain left atrial-ventricular volumes. Left atrial-ventricular volume loops were established according to left atrial-ventricular volumes after analysis. Morphological characteristics of LA-LV V-LOOPs and volumes of left atrial-ventricular were compared among healthy adults of different age as well as different genders to assess left heart function. Results. LA-LV V-LOOPs showed an upward shift between the youth group and the middle-age group, as well as between the middle-age group and the old group in the coordinate axis. Left ventricular volume indexes of male group were higher than that of female group at 25% (56.89(IQR66.14-47.43) VS 48.30(IQR57.98-43.14), P=0.051), 50% (42.10(IQR48.56-32.45) VS 33.10(IQR41.50-30.37), P=0.037), 75% (28.18(IQR36.94-24.94) VS 23.89(31.66-21.17), P=0.042) of left ventricular systole. Conclusion. LA-LV V-LOOPs could intuitively reflect the variety of left atrial-ventricular function by different positions of LA-LV V-LOOPs on the coordinate axis among adults of different ages and sexes.