Concomitant synthesis and stabilization of selenium nanoparticles using extract of endophytic fungus, Nigrospora gullinensis

Research Square (Research Square)(2022)

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摘要
Abstract Selenium has many beneficial bioactive properties yet has a narrow therapeutic window. This problem can be addressed by selenium in nanoform or selenium nanoparticles (SeNPs). There are several chemical and physical approaches that can be employed for the synthesis of SeNPs. However, the biological route for SeNP synthesis is known to be more eco-friendly, economical, and biocompatible when assessing bioactivities. The present study demonstrates a biological approach that effectively facilitates the synthesis and stabilization of SeNPs with the help of secondary metabolites derived from endophytic fungi. These capped SeNPs show prominent bioactivity in terms of in vitro anti-oxidant properties and anti-microbial activity on Escherichia coli, Enterobacter faecalis, and Staphylococcus aureus. The results indicated NL(C)-SeNPs portray potential anti-oxidant and anti-microbial activity. However, additional studies related to the toxicity and synergistic effects of SeNPs, are required before their therapeutic applications.
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selenium nanoparticles,endophytic fungus,nigrospora gullinensis
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