Supramolecular carbohydrate-based hydrogels from oxidative hydroxylation of amphiphilic β-C-glycosylbarbiturates and α-glucosidase-induced hydrogelation

An ecofriendly two-step synthesis in water enabled the obtention of neutral amphiphilic β-C-glycosylbarbiturates with self-assembly properties capable of supramolecular hydrogelation. And, an α-glucosidase induced sol-to-gel phase transition.