Excavate the role of E2F family in the prognosis, drug sensitivity analyses, and Immune cell infiltration of KIRC (Kidney Clear Cell Carcinoma)

Abstract KIRC is a common malignant tumor with few early symptoms, usually been found and diagnosed when it becomes large with hematuria, kidney injury and abdominal mass. E2F family include 8 genes (E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, E2F7 and E2F8) and express high in virtually all cancers. Their role in cell proliferation has been extensively studied. Regrettably, there are very few reports about the interrelationship between KIRC and E2Fs. In order to research their relation, by taking great advantage of some reliable datasets and bioinformaticsx tools, we excavated the expression level of E2Fs, the prognostic value of E2Fs in KIRC, co-expression network, drug sensitivity analysis, kinase target and immune cell infiltration of E2Fs in KIRC patient. Our work may provide new insights into the selection of immunotherapeutic targets and prognostic biomarkers for KIRC. It also provides more data to help clinicians select appropriate therapeutic agents and more accurately predict the long-term prognosis of patients with renal cancer. Method: GEPIA, UALCAN, cBioPortal, GeneMANIA, DAVID 6.8, Metascape, TRRUST, TIMER, and LinkedOmics were used in this study.