1956. Impact of an Implementation Science-Based Project to Address COVID-19 Vaccine Hesitancy

Abstract Background COVID-19 vaccine uptake remains suboptimal. This project aimed to identify and mitigate reasons for vaccine hesitancy. Baseline patient knowledge and attitudes about COVID-19 vaccination Methods Between 9/2021 and 1/2022, 16 live in-person and/or virtual patient education programs were held in community centers/clinics in NC and GA. Surveys were administered before/after each session, and longitudinal outcomes 3 weeks later. Results Surveys were conducted amongst the 1381 participating patients. 64% were already fully vaccinated against COVID-19, 19% had received 1 of 2 doses, and 17% were either unvaccinated (14%) or unsure of their status (3%). Baseline vaccine knowledge was higher among fully vaccinated patients, with patient attitudes varied per vaccination status (Figure). Patients not planning to get vaccinated cited concern for long-term (21%) and short-term (18%) side effects, thinking the vaccines were developed too quickly (16%), not feeling the vaccine would protect them (10%), and not feeling at risk for serious illness (10%). When asked what they thought would increase patient interest in vaccination, providers (n = 28) identified a strong recommendation (39%) or more information (36%) from a patient’s own doctor, while patients prioritized transportation (28%) , vaccine availability in their doctor’s office (23%), and information from their doctor (23%). Provider confidence in counseling patients improved after the program; more providers felt confident discussing vaccine safety (69%) and efficacy (69%) after the program than at baseline (33% and 41%, respectively). More patients felt confident sharing COVID-19 vaccine information with family and friends after the program (73%) than before (53%). Gains in patient views about COVID-19 vaccination were greatest among those who were unvaccinated/unsure; among this group, more patients agreed that vaccines are safe (72%), effective (76%), and important (78%) after the education, compared to 42%, 46%, and 52% at baseline, respectively. In the longitudinal patient follow-up survey 86% of unvaccinated patients got vaccinated after completing the education session. Conclusion Patient knowledge and attitudes varied based on vaccine experience, as did patient and provider perceptions about improving vaccine acceptance. Vaccine uptake was high following the program. Disclosures Scott C. Ratzan, MD, MPA, Abbvie: Stocks/Bonds|Astra Zeneca: Stocks/Bonds|baxter: Stocks/Bonds|Bristol Myers Squibb: Stocks/Bonds|Merck: Grant/Research Support|Quest Diagnostics: Stocks/Bonds|United Health Group: Stocks/Bonds|Usana Health. Services: Stocks/Bonds|vertex: Stocks/Bonds.