A novel technique based on mutual information weighted feature selection to predict chronic kidney disease.

Chronic Kidney Disease (CKD) is a crucial life-threatening condition due to impaired kidney functionality and renal disease. In recent studies, Kidney disorder is considered one of the essential and deadliest issues that threaten patients' survival with the lack of earlier prediction and classification. The earlier prediction process and the proper diagnosis help delay or stop the chronic disease progression into its final stage, where renal transplantation or dialysis is a known way of saving the patient's life. Global studies reveal that nearly 10% of the population is affected by Chronic Kidney Disease (CKD), and millions die because of non-affordable treatment. Early detection of CKD from the biological parameters would save people from this crisis. Machine Learning algorithms are playing a predominant role in disease diagnosis and prognosis. This work generates compound features from CKD indicators by two novel algorithms: Correlation-based Weighted Compound Feature (CWCF) and Feature Significance basedWeighted Compound Feature (FSWCF). Any learning algorithm is as good as its features. Hence, the features generated by these algorithms are validated on different machine learning algorithms as a test for generality. The simulation is done in MATLAB 2020a environment where various metrics like prediction accuracy gives superior results compared to multiple other approaches. The accuracy of CWCF over different methods like LR is 97.23%, Gaussian NB is 99%, SVM is 99.18%, and RF is 99.89%, which is substantially higher than the approaches without proper methods feature analysis. The results suggest that generated compound features improve the predictive power of the algorithms.