Prediction of disease specific and overall survival in men with prostate cancer using the Decipher assay

Objectives This is a protocol for a Cochrane Review (prognosis). The objectives are as follows: To determine the prognostic value of the Decipher gene assay in men with biopsy‐confirmed clinically localized prostate cancer before and after receiving treatment. This objective can be framed in two questions following the population, index prognostic factor, comparator prognostic factor(s), outcome, timing, and setting (PICOTS) format as illustrated in Table 1. Table 1. Review question in PICOTS format Objective Before treatment After treatment Population Men with newly diagnosed, biopsy‐confirmed clinically localized prostate cancer Men who have undergone radical prostatectomy for clinically localized prostate cancer Index prognostic factor Decipher gene assay Comparator Existing clinical prediction models Outcome Overall survival and prostate‐cancer survival Timing The outcome is to be predicted at any point after diagnosis Setting Before primary, local treatment with curative intent Following primary surgical treatment with curative intent