Senoprotective Effects Of Mesenchymal Stromal Cells-Derived Extracellular Vesicles In Osteoarthritis

Purpose: Age is the most important risk factor in osteoarthritis (OA) and is associated with the accumulation of senescent cells that contribute to the functional decline of the joint. Currently, no curative therapeutic options can be provided to OA patients. In this context, the therapeutic effect of mesenchymal stromal cells and their extracellular vesicles (MSC-EVs) has been demonstrated in preclinical models. Here, we aimed to investigate the impact of adipose tissue MSC-EVs (ASC-EVs) on senescence using both in vitro and in vivo models of OA.