Abstract P525: Associations of Body Mass Index Variability From Childhood and Midlife Dyslipidemia

Background: In adults, short periods of weight loss followed by weight gain, known as body mass index(BMI) variability, has been linked to adverse cardiovascular outcomes. However, the impact of long-term BMI variability from childhood on midlife dyslipidemia is unclear. We identified this effect in a cohort of Black and White midlife adults living in a rural community. Methods: We studied 1,268 midlife participants of the Bogalusa Heart Study (age at baseline 9.5 ± 3.5 years, age at midlife 48.2 ± 5.2 years, 59.5% women, 34.4% black) with ≥4 measurements of BMI and other traditional cardiovascular risk factors (CVRF) from childhood. Long-term BMI variability was computed as deviation from age-predicted values (DEV). The associations between long-term BMI variability and dyslipidemia and dyslipidemia subtypes were assessed by logistic regression, adjusting for age, sex, race, CVRF, depression, alcohol use, education, and employment status. Interactions between race, sex and long-term BMI variability were assessed. Results: Prevalence of midlife dyslipidemia were 88.01%(n=1116). DEV was positively significantly associated with having midlife dyslipidemia. Stratified analyses showed that men had higher odds of having midlife dyslipidemia, HDL-C<60 mg/dL, and triglycerides ≥150 mg/dL with 1 unit increase in DEV, compared to those of women. White participants had higher odds of having triglycerides ≥150 mg/dL with 1 unit increase in DEV compared to Black participants. (see Table 1) Conclusions: We identified associations between long-term BMI variability from childhood and midlife dyslipidemia. Race and sex were found to modify the associations of long-term BMI variability on having midlife dyslipidemia and dyslipidemia subtypes. Further studies are needed to determine the role of long-term BMI variability as a predictor for increased risk of midlife dyslipidemia.