Panitumumab in combination with chemoradiotherapy for the treatment of locally-advanced anal canal carcinoma: results of the FFCD 0904 phase II trial

Véronique Vendrely,Philippe Ronchin,Mathieu Minsat,Karine Le Malicot,Claire Lemanski,Xavier Mirabel,Pierre-Luc Etienne,Astrid Lièvre,Ariane Darut-Jouve,Christelle de la Fouchardière,Nicolas Giraud,Gilles Breysacher, Delphine Argo-Leignel, Elsa Thimonnier,Nicolas Magné,Meher Ben Abdelghani,Côme Lepage,Thomas Aparicio

Radiotherapy and Oncology（2023）

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摘要

Panitumumab in combination with CRT for locally advanced SCCA failed to meet the expected CR rate and exhibited a poor tolerance. Furthermore, late RFS, CFS, and OS did not suggest any outcome improvement to justify further clinical trials.

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关键词

Anal cancer, Squamous cell carcinoma, Epidermal growth factor receptor, Panitumumab, Chemoradiotherapy, Immunotherapy

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