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Structure–activity Relationship Study of Central Pyridine-Derived TYK2 JH2 Inhibitors: Optimization of the PK Profile Through C4′ and C6 Variations

Zili Xiao,Michael G. Yang,Chunjian Liu,Trevor Sherwood,John L. Gilmore,James Lin,Peng Li,Dauh-Rurng Wu,John Tokarski,Sha Li,Lihong Cheng,Chunshan Xie,Jingsong Fan,Elizabeth Dierks,Joann Strnad,Mary Ellen Cvijic,Javed Khan,Max Ruzanov,Michael Galella,Purnima Khandelwal,Alaric J. Dyckman,Arvind Mathur,Louis J. Lombardo,John E. Macor,Percy H. Carter,Nelly Aranibar,James R. Burke,David S. Weinstein

Bioorganic & Medicinal Chemistry Letters（2023）

Cited 0|Views37
Key words
TYK2 JH2 inhibitor,JAK,Autoimmune diseases
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