Effect of Apremilast on LPS-induced immunomodulation and inflammation via activation of Nrf2/HO-1 pathways in rat lungs

Naif O. Al-Harbi,Faisal Imam,Mohammad Matar Al-Harbi,Wajhul Qamar,Khaldoon Aljerian,Md. Khalid Anwer,Mohammed Alharbi,Sultan Almudimeegh,Abdullah S. Alhamed,Ali A Alshamrani

Saudi Pharmaceutical Journal（2023）

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摘要

•Lipopolysaccharides induces inflammation and immunomodulation.•Lipopolysaccharides decreases CD161+ T cells population while decreases CD31b/c+ Cells population during acute lung injury.•Apremilast ameliorates lipopolysaccharides-induced lung inflammation.•Apremilast treatment prevent lipopolysaccharides-induced lung inflammation and immunomodulation via Nrf2/HO-1 signaling.

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关键词

Apremilast,Lipopolysaccharides,Heme-oxygenase,Nitric oxide synthase-2,Western blot,Polymerase chain reaction

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