Targeted chitosan nanobubbles as a strategy to down-regulate microRNA-17 into B-cell lymphoma models.

Sara Capolla,Monica Argenziano,Sara Bozzer,Tiziana D'Agaro,Tamara Bittolo,Luigina De Leo, Tarcisio Not,Davide Busato,Michele Dal Bo,Giuseppe Toffoli,Roberta Cavalli,Valter Gattei,Riccardo Bomben,Paolo Macor

Frontiers in Immunology（2023）

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摘要

Anti-CD20 targeted NBs investigated in this study showed physico-chemical and stability properties suitable for antagomiR17 delivery and represent a useful nanoplatform to address B-cell malignancies or other cancers through the modification of their surface with specific targeting antibodies.

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关键词

lymphoma,miR (microRNA),nanobubble,targeting antibody,animal model

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