The Direct and Long-Term Effects of Raloxifene as Adjunctive Treatment for Schizophrenia-Spectrum Disorders: A Double-Blind, Randomized Clinical Trial.

Bodyl A Brand,Janna N de Boer,Machteld C Marcelis,Koen P Grootens,Jurjen J Luykx,Iris E Sommer

SCHIZOPHRENIA BULLETIN（2023）

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摘要

Our results do not support the use of raloxifene in patients with SSD in general, but suggest female-specific beneficial effects of raloxifene on negative symptoms and working memory. Our findings encourage further research on sex-specific pharmacotherapeutic treatment.

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关键词

RCT,schizophrenia,estrogen,SERM,raloxifene,antipsychotic medication,sex differences

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