Atypical Neurogenesis, Astrogliosis, and Excessive Hilar Interneuron Loss Are Associated with the Development of Post-Traumatic Epilepsy.

Erwin Kristobal Gudenschwager-Basso,Oleksii Shandra, Troy Volanth,Dipan C Patel,Colin Kelly, Jack L Browning,Xiaoran Wei, Elizabeth A Harris,Dzenis Mahmutovic,Alexandra M Kaloss,Fernanda Guilhaume Correa,Jeremy Decker,Biswajit Maharathi,Stefanie Robel,Harald Sontheimer,Pamela J VandeVord,Michelle L Olsen,Michelle H Theus

Cells（2023）

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摘要

These findings suggest that epileptogenesis may emerge following TBI due to distinct aberrant cellular remodeling events and key molecular changes in the dentate gyrus of the hippocampus.

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关键词

traumatic brain injury,hippocampus,granular neurons,neuroblasts,seizures,epilepsy,PTE

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