New Insights into the Impact of Human Papillomavirus on Oral Cancer in Young Patients: Proteomic Approach Reveals a Novel Role for S100A8.

Marisol Miranda-Galvis, Carolina Carneiro Soares,Carolina Moretto Carnielli,Jaqueline Ramalho Buttura,Raisa Sales de Sá,Estela Kaminagakura,Fabio Albuquerque Marchi,Adriana Franco Paes Leme,Clóvis A Lópes Pinto,Alan Roger Santos-Silva,Rogerio Moraes Castilho,Luiz Paulo Kowalski,Cristiane Helena Squarize

Cells（2023）

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摘要

HPV (+) OSCC has a peculiar microenvironment pattern distinctive from HPV (-), involving the expression of pathogen-associated pattern receptors, S100A8 overexpression, and NFκB activation and responses, which has important consequences in prognosis and may guide therapeutic decisions.

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oral cancer,HPV,proteomics,prognosis

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