The effect of Helicobacter pylori eradication treatment with amoxicillin, gemifloxacin and rabeprazole on inflammatory parameters

Aim: Inflammation of the gastric mucosa caused by H. pylori is usually chronic and lasts a lifetime. This permanent colonization results in the mucosal expression of chemotactic factors that attract neutrophils and mononuclear cells. Despite the known production of proinflammatory cytokines in stomach mucosa and infiltration of inflammatory cells, there are few studies in the literature related to the effects of these and changes after treatment. The aim of this study was to evaluate patients determined with H.pylori positivity endoscopically and histopathologically, and to investigate the change in inflammatory parameters after successful eradication treatment with gemifloxacin, amoxicillin and rabeprazole.Material and Methods: This study included 126 patients who presented with dyspeptic complaints between April 2022 and September 2022, who were determined as HP-positive from stomach tissue biopsies taken under upper gastrointestinal system (GIS) endoscopy in the Gastroenterology Endoscopy Unit, and were then determined with successful eradication following the treatment given. Demographic data (age, gender) of all the patients were documented. Blood samples were taken for analysis before the treatment and after successful HP eradication treatment.Results: The patients consisted of 72 (57.1%) females and 54 (42.9%) males with a mean age of 40.7 +/- 13.8 years (range, 18-65 years). Statistically significant differences were determined in the comparisons of the inflammatory parameters before and after treatment in patients with successful H.pylori eradication.Discussion: Although H.pylori seems to be a local infection, persistent inflammation results in long-term gastric and extra-gastric effects. A reduction in inflammatory parameters with successful eradication reduces the long-term effects that can develop.