Bimetallic Pd/Cu‐Catalyzed Sonogashira Coupling‐Elimination Reaction: An Efficient Synthesis of 2‐Unsubstituted Terminal 1, 3‐Enynes
ASIAN JOURNAL OF ORGANIC CHEMISTRY(2023)
摘要
Herein, an efficient strategy to synthesize 2-unsubstituted terminal 1, 3-enynes in high yields by bimetallic Pd/Cu-catalyzed Sonogashira coupling-elimination reaction of iodobenzenes with 4-bromobut-1-yne was reported. To our knowledge, this is the first report of 4-bromobut-1-yne as an efficient 1, 3-enynes reagent, and the method is more convenient and cost-effective than other reported synthetic methods, which are hindered by the laborious preparation of starting materials, the high cost of bromoethene, and the inconvenient handling of gas acetylene.
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关键词
2-Unsubstituted terminal 1, 3-enynes,Bimetallic Pd/Cu-catalyzed,Sonogashira coupling-elimination,4-Bromobut-1-yne
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