Paired electrolysis enables decarboxylative coupling of alkenyl acids with diazo compounds
ORGANIC CHEMISTRY FRONTIERS(2023)
摘要
Herein, we have reported an efficient and green paired electrolysis strategy for decarboxylative coupling of alkenyl acids with diazo compounds, providing a broad range of beta,gamma-alkenyl esters and amides. The method features high stereoselectivity and no involvement of transition metals and chemical redox regents. Moreover, the protocol also provides a facile access to the corresponding dideuterated products with a high level of deuterium incorporation (93-99% D-inc.) by directly using D2O, thus unveiling the method as being highly valuable. Mechanistic studies reveal that diazo compounds are converted into carbon radicals using H2O as a promoter at the cathode through a proton-coupled electron transfer (PCET) process.
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关键词
decarboxylative coupling,alkenyl acids,electrolysis,compounds
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