Novel high yielding route for the synthesis of Melphalan dimer impurity G
INDIAN JOURNAL OF CHEMISTRY(2023)
摘要
Melphalan dimer is an impurity from the synthesis of Melphalan (M216900) which is an antineoplastic agent. In this article, a new route for the synthesis of Melphalan dimer impurity G has been discussed. The new research provides the first high-yield, high-purity synthesis of this impurity. The impurity has been confirmed for purity using HPLC, and its structure has been identified using MS, 1H and 13C NMR.
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关键词
Melphalan, Impurity, Synthesis, Dimer impurity, Antineoplastic agent
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