Subthalamic nucleus stimulation attenuates motor seizures via modulating the nigral orexin pathway.

Tao Xue,Shu Wang,Shujun Chen,Huizhi Wang,Chong Liu,Lin Shi,Yutong Bai,Chunkui Zhang,Chunlei Han,Jianguo Zhang

Frontiers in neuroscience（2023）

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摘要

STN-DBS helps reduce motor seizure activity by inhibiting the STN-SNr circuit. Additionally, orexin receptor antagonists show potential in suppressing motor seizure activity and may be a promising therapeutic option in the future.

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关键词

subthalamic nucleus,substantia nigra pars reticulata,deep brain stimulation,motor seizure,orexin

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