Malignancy in disguise: ALK-positive anaplastic large cell lymphoma with refractory hyperinflammation and CNS involvement

PEDIATRIC BLOOD & CANCER(2023)

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Pediatric Blood & CancerEarly View e30415 LETTER TO THE EDITOR Malignancy in disguise: ALK-positive anaplastic large cell lymphoma with refractory hyperinflammation and CNS involvement Zhongbo Hu, Corresponding Author Zhongbo Hu [email protected] orcid.org/0000-0002-8935-0626 Hospitalist Medicine Program, Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA Correspondence Zhongbo Hu, 262 Danny Thomas Pl, Mail Stop 278, Memphis, TN 38105, USA. Email: [email protected]Search for more papers by this authorTrisha K. Paul, Trisha K. Paul Department of Pediatric Hematology Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USASearch for more papers by this authorYen-Chun Liu, Yen-Chun Liu Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USASearch for more papers by this authorMary E. McCarville, Mary E. McCarville orcid.org/0000-0002-2888-443X Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee, USASearch for more papers by this authorMelissa Hines, Melissa Hines Critical Care Medicine Pediatric Medicine Department, St. Jude Children's Research Hospital, Memphis, Tennessee, USASearch for more papers by this authorGabriela Gheorghe, Gabriela Gheorghe Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USASearch for more papers by this authorPatrick K. Campbell, Patrick K. Campbell Department of Oncology and Information Services, St. Jude Children's Research Hospital, Memphis, Tennessee, USASearch for more papers by this author Zhongbo Hu, Corresponding Author Zhongbo Hu [email protected] orcid.org/0000-0002-8935-0626 Hospitalist Medicine Program, Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA Correspondence Zhongbo Hu, 262 Danny Thomas Pl, Mail Stop 278, Memphis, TN 38105, USA. Email: [email protected]Search for more papers by this authorTrisha K. Paul, Trisha K. Paul Department of Pediatric Hematology Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USASearch for more papers by this authorYen-Chun Liu, Yen-Chun Liu Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USASearch for more papers by this authorMary E. McCarville, Mary E. McCarville orcid.org/0000-0002-2888-443X Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee, USASearch for more papers by this authorMelissa Hines, Melissa Hines Critical Care Medicine Pediatric Medicine Department, St. Jude Children's Research Hospital, Memphis, Tennessee, USASearch for more papers by this authorGabriela Gheorghe, Gabriela Gheorghe Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USASearch for more papers by this authorPatrick K. Campbell, Patrick K. Campbell Department of Oncology and Information Services, St. Jude Children's Research Hospital, Memphis, Tennessee, USASearch for more papers by this author First published: 17 May 2023 https://doi.org/10.1002/pbc.30415Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. REFERENCES 1Setiadi A, Zoref-Lorenz A, Lee CY, Jordan MB, Chen LYC. Malignancy-associated haemophagocytic lymphohistiocytosis. Lancet Haematol. 2022; 9(3): e217- e227. doi:10.1016/S2352-3026(21)00366-5 2Stadler S, Singh VK, Knorr F, Damm-Welk C, Woessmann W. Immune response against ALK in children with ALK-positive anaplastic large cell lymphoma. Cancers (Basel). 2018; 10(4): 114. doi:10.3390/cancers10040114 3Raffa EH, Branson HM, Ngan B, Alexander S, Abla O. Central nervous system relapse in a child with anaplastic large cell lymphoma: potential for new therapeutic strategies. Cancer Rep (Hoboken). 2021; 4(5):e1377. doi:10.1002/cnr2.1377 4Turner SD, Lamant L, Kenner L, Brugieres L. Anaplastic large cell lymphoma in paediatric and young adult patients. Br J Haematol. 2016; 173(4): 560- 572. doi:10.1111/bjh.13958 5Williams D, Mori T, Reiter A, et al. Central nervous system involvement in anaplastic large cell lymphoma in childhood: results from a multicentre European and Japanese study. Pediatr Blood Cancer. 2013; 60(10): E118- E121. doi:10.1002/pbc.24591 6Chun SG, Choe KS, Iyengar P, Yordy JS, Timmerman RD. Isolated central nervous system progression on crizotinib: an Achilles heel of non-small cell lung cancer with EML4-ALK translocation? Cancer Biol Ther. 2012; 13(14): 1376- 1383. doi:10.4161/cbt.22255 7Del Baldo G, Abbas R, Woessmann W, et al. Neuro-meningeal relapse in anaplastic large-cell lymphoma: incidence, risk factors and prognosis - a report from the European intergroup for childhood non-Hodgkin lymphoma. Br J Haematol. 2021; 192(6): 1039- 1048. doi:10.1111/bjh.16755 8Solomon BJ, Besse B, Bauer TM, et al. Lorlatinib in patients with ALK-positive non-small-cell lung cancer: results from a global phase 2 study. Lancet Oncol. 2018; 19(12): 1654- 1667. doi:10.1016/S1470-2045(18)30649-1 9Bagchi A, Orr BA, Campagne O, et al. Lorlatinib in a child with ALK-fusion-positive high-grade glioma. N Engl J Med. 2021; 385(8): 761- 763. doi:10.1056/NEJMc2101264 Early ViewOnline Version of Record before inclusion in an issuee30415 ReferencesRelatedInformation
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cell lymphoma,refractory hyperinflammation
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