DEPICTER2: a comprehensive webserver for intrinsic disorder and disorder function prediction

Intrinsic disorder in proteins is relatively abundant in nature and essential for a broad spectrum of cellu-lar functions. While disorder can be accurately pre-dicted from protein sequences, as it was empiri-cally demonstrated in recent community-organized assessments, it is rather challenging to collect and compile a comprehensive prediction that covers multiple disorder functions. To this end, we intro-duce the DEPICTER2 (DisorderEd PredictIon Cen-TER) webserver that offers convenient access to a curated collection of fast and accurate disorder and disorder function predictors. This server includes a state-of-the-art disorder predictor, flDPnn, and five modern methods that cover all currently predictable disorder functions: disordered linkers and protein, peptide, DNA, RNA and lipid binding. DEPICTER2 al-lows selection of any combination of the six meth-ods, batch predictions of up to 25 proteins per re-quest and provides interactive visualization of the re-sulting predictions. The webserver is freely available at http://biomine.cs.vcu.edu/servers/DEPICTER2/