Increased bioavailability of diosmetin-7-glucoside-gamma-cyclodextrin inclusion complex compared with diosmin in Sprague-Dawley rats

Masamitsu Moriwaki,Kento Kito,Ryo Nakagawa,Mahendra P. Kapoor,Yoshiki Matsumiya,Tomohisa Fukuhara,Junya Kobayashi,Kensuke Satomoto,Hiroshi Yamagata,Yuichi Kuroiwa

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY（2023）

引用 0|浏览1

暂无评分

摘要

Diosmin (DSN) is found mainly in citrus fruits, and has potent antioxidant effects. This study aimed to evaluate pharmacokinetics of diosmetin-7-glucoside-gamma-cyclodextrin (DIOSG-CD) inclusion complex. The area under the curve values from AUC(0)(-)(24) of DIOSG-CD, prepared by reacting DSN and naringinase with gamma-CD, were approximately 800-fold higher than those of DSN following their administration in Sprague-Dawley rats.

查看译文

关键词

diosmin, diosmetin-7-glucoside-gamma-cyclodextrin, naringinase, chronic venous insufficiency

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要