Drug mechanism enrichment analysis improves prioritization of therapeutics for repurposing.

Belinda B. Garana,James H. Joly,Alireza Delfarah,Hyunjun Hong,Nicholas A. Graham

BMC Bioinform.（2023）

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摘要

DMEA is a versatile bioinformatic tool that can improve the prioritization of candidates for drug repurposing. By grouping drugs with a shared MOA, DMEA increases on-target signal and reduces off-target effects compared to analysis of individual drugs. DMEA is publicly available as both a web application and an R package at https://belindabgarana.github.io/DMEA .

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关键词

Drug repurposing, Mechanism of action, Precision medicine, Targeted therapeutics, Enrichment analysis, Gene expression analysis, Proteomic analysis, Senescence, Senolytic

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