Blood Pressure, Incident Cognitive Impairment, and Severity of CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study

Rationale & Objective: Hypertension is a known adults with chronic kidney disease. We sought to identify and characterize the relationship among blood pressure, cognitive impairment, and with chronic kidney disease. Setting & Participants: 3,768 participants in the Exposure: Baseline SBP and DBP were examined as exposure variables, using continuous (linear, per 10-mm Hg higher), categorical (SBP < 120 [reference], 120 to 140, > 140 mm Hg; DBP < 70 (reference), 70 to 80, > 80 mm Outcome: Incident cognitive impairment defined as a decline in Modified Mini-Mental State Examination (3MS) score to greater than 1 standard deviation below the cohort mean.