Nobiletin inhibits de novo FA synthesis to alleviate gastric cancer progression by regulating endoplasmic reticulum stress

Menglin Chen,Ruijuan Zhang,Yaling Chen,Xu Chen,Yaqi Li,Junyu Shen,Mengyun Yuan,Yuxuan Chen,Jian Wu,Qingmin Sun

Phytomedicine（2023）

引用 2|浏览5

暂无评分

摘要

NOB could inhibit the expression of ACLY to activate IRE-1α-induced ER stress, which ultimately led to GC cell apoptosis. Our results provide novel insight into the use of de novo FA synthesis for GC treatment and are the first to reveal that NOB inhibits GC progression by ACLY-dependent ER stress.

查看译文

关键词

Gastric cancer, Nobiletin, De novo FA synthesis, ER stress

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要