Hemoglobin Variant in Disguise

V. Higgins, L. MacNeil,I. Sosova, R. Ridsdale, A. Bruce,D. Brinc, W. David, J. Rara, P. Bordeleau, M.P. Estey, M.L. Parker, Ismail Oz, T. Agbor

Clinical Biochemistry（2023）

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摘要

•Hb Olupona migrates as HbA on capillary and gel electrophoresis, as well as HPLC.•HbS percentage is higher than expected when co-inherited with Hb Olupona.•Hb Olupona is likely clinically silent, but its significance remains uncertain.•Molecular testing is the most confirmatory method to identify hemoglobin variants.

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关键词

Hemoglobinopathy, Hemoglobin variant, Sickle cell trait, Hb Olupona

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