HucMSC-Exo Promote Mucosal Healing in Experimental Colitis by Accelerating Intestinal Stem Cells and Epithelium Regeneration via Wnt Signaling Pathway

Xiaonan Liang,Chenyang Li,Jia Song,Airu Liu,Chen Wang,Wenxin Wang,Yaxing Kang,Donglei Sun,Jiaming Qian,Xiaolan Zhang

International Journal of Nanomedicine（2023）

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摘要

Our results suggested that hucMSC-exo could facilitate mucosal healing in experimental colitis by accelerating ISCs and intestinal epithelium regeneration via transferring key miRNAs, which was dependent on the activation of Wnt/β-catenin signaling pathway.

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关键词

inflammatory bowel disease, mesenchymal stem cells, exosome, mucosal healing, Wnt, 13-catenin signaling pathway

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