Heterogeneous distribution of EGFR mutation in NSCLC: Case report

Sara Boukansa,Zineb Benbrahim, Sanaa Gamrani, Ismail Mouhrach,Fatima El Agy,Sanae El Bardai,Laila Bouguenouch,Mounia Serraj,Bouchra Amara,Yassine Ouadnouni,Mohamed Smahi,Badreeddine Alami,Nawfel Mellas,Hinde El Fatemi

Respiratory Medicine Case Reports（2023）

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摘要

Both sensitivity and specificity of molecular methods can provide evidence of intratumoral heterogeneity, which may explain the mismatch between the validation of oncology biomarkers and predicting therapeutic response to targeted therapy.

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关键词

EGFR mutation,S768I,intratumoral heterogeneity,Real Time PCR,Pyrosequencing

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