Semisynthesis reveals apoptin as a tumour-selective protein prodrug that causes cytoskeletal collapse

Jasmine Wyatt, Yuen Ka Chan, Mateusz Hess,Mahvash Tavassoli,Manuel M. Müller

Chemical Science（2023）

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摘要

Structure-activity studies with site-specifically modified apoptin in living cells demonstrate that this protein's toxicity is mediated by phosphorylation and downstream interactions with the cytoskeleton.

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