Regulation of TGF-β1-Smad-1-7 signaling to Inhibit Epithelial Mesenchymal Transition by Repurposed Anti-Fibrotic Drug Pirfenidone can Attenuate Lung Cancer Progression

Ritu Kulshrestha, Pawan Kumar,Amit Singh, Divya S Nair, Meenu R, Himanshu Dhanda,Apoorva Pandey, Dahiya R, Mishra AK, Dinda AK

Journal of cancer science and clinical therapeutics（2023）

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摘要

Background: Lung cancer cells undergo EMT, and metastasize to preferential sites such as brain, bone and adrenal glands. Pirfenidone is an anti-fibrotic agent used for treatment of pulmonary fibrosis. Its efficacy as therapeutic adjuvant in lung cancer via regulation of TGF-β1-Smad-1-7- EMT signaling is postulated.

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关键词

lung cancer progression,lung cancer,epithelial mesenchymal transition,anti-fibrotic

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