Phenotypic characterization of colorectal liver metastases: capsule versus no capsule and the potential role of epithelial mesenchymal transition

Background Colorectal liver metastases (CRLM) can be encased in a fibrous capsule separating cancer from normal liver tissue, which correlates with increased patient survival. This study elucidates cellular and molecular mechanisms of capsule formation and the possible role of epithelial mesenchymal transition (EMT).