MK2 limits the production of distinct acute-phase proteins by controlling the composition of gene expression modulators

When faced with a pathogenic challenge, the liver displays a strong innate immune response by producing many acute-phase proteins (APPs). APPs counteract tissue damage and regulate repair processes. They also isolate and neutralize invading pathogens and prevent further pathogen entry. The expression of APPs by hepatocytes is induced by inflammatory cytokines, which are mainly released by macrophages. Many of the molecular mediators involved here are controlled by the protein kinase MK2. However, to date it is unknown, if MK2 plays a role for hepatic APP synthesis. Therefore, the aim of this study is to reveal MK2-dependent mechanisms involved in the regulation of APP synthesis in the liver.