IDH1 targeting as a potential treatment for intrahepatic cholangiocarcinoma (iCCA)

Agnieszka Seretny, Lio Böse, Luise Butthof, Kai Volz, Peter Macsek, Julius Michel,Khwab Sanghvi,Stefan Pusch,Theresa Bunse, DarjusFelix Tschaharganeh

39. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der LeberZeitschrift für Gastroenterologie（2023）

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摘要

Gain-of-function mutations in IDH1 render it with a neomorphic activity to produce an oncometabolite, 2-hydroxyglutarate (2-HG). Little is known about the relevance of this phenomenon in intrahepatic cholangiocarcinoma (iCCA), even though this gene is among the most frequently mutated genes in this tumor type. Furthermore, mutated IDH1 could serve as an important potential target for exploring novel therapeutic options for iCCA.

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关键词

intrahepatic cholangiocarcinoma,icca

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