Evaluation of the Immune Microenvironment in Sinonasal Undifferentiated Carcinoma and Its Association with Patients’ Survival

Background: Sinonasal undifferentiated carcinoma (SNUC) is a rare, highly aggressive cancer that arises in the nasal cavity and paranasal sinuses. Despite aggressive multimodal therapy the prognosis remains poor. To better manage patients with SNUC, identification of survival predictors and new therapeutic options for SNUC treatments, including immunotherapy are crucial. The aim of this study was to evaluate the signature of the tumor immune microenvironment and analyze its correlation with clinical outcomes in SNUC.