PSMB4 Degrades the Porcine Reproductive and Respiratory Syndrome Virus Nsp1α Protein via the Autolysosome Pathway and Induces the Production of Type I Interferon

Heyou Yi,Qiumei Wang, Lechen Lu,Ruirui Ye,Ermin Xie,Zhiqing Yu,Yankuo Sun,Yao Chen,Mengkai Cai,Yingwu Qiu,Qianwen Wu,Jie Peng,Heng Wang,Guihong Zhang

Journal of Virology（2023）

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摘要

In the swine industry, PRRSV is a continuous threat, and the current vaccines are not effective enough to block it. This study determined that PSMB4 plays an antiviral role against PRRSV.

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关键词

autolysosome pathway,virus,porcine reproductive,protein

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